顾宁 理学博士，教授，博士生导师。主要研究方向：干细胞增殖与分化机制、体细胞重编程等研究；糖尿病，肥胖症等内分泌疾病的发病机制与治疗方法的研究；纳米粒子及小分子化合物的药理研究。
1998年4月—2002年3月在日本京都教育大学攻读并获得学士学位，2002年4月—2004年3月在日本京都大学攻读并获得硕士学位，2004年4月—2007年3月在日本京都大学攻读并获得博士学位，2007年4月—2009年3月在日本京都大学学术振兴会（JSPS）从事研究员工作，2009年4月—2010年1月前往日本产业技术综合研究所任研究员，2010年1月开始被哈尔滨工业大学生命科学与技术学院聘为副教授。近年来主要承担项目有：国家自然科学基金、城市水资源与水环境国家重点实验室项目。研究成果连续发表在《Diabetes Technology & Therapeutics》、《Clinical and Experimental Pharmacology and Physiology》、《Biochemical and Biophysical Research Communications》、《Journal of Nutritional Science and Vitaminology》等期刊。
近期发表的有关论文:
1) Guo Qian, Jin Sanli, Hu Hailong, Zhou Ying, Yan Yuheng, Zong He, Wang Yu, He Hongjuan, Oh Yuri, Liu Chuanpeng, Gu Ning. Hypoxia in 3T3-L1 adipocytes suppresses adiponectin expression via the PERK and IRE1 unfolded protein response. Biochem Biophys Res Commun 2017 Sep;.
2) Hu Hailong, Li Li, Guo Qian, Jin Sanli, Zhou Ying, Oh Yuri, Feng Yujie, Wu Qiong, Gu Ning, A mechanistic study to increase understanding of titanium dioxide nanoparticles-increased plasma glucose in mice.Food Chem Toxicol. 2016 Sep;95:175-81.
3) Gu Ning, Hu Hailong, Guo Qian, Jin Sanli, Wang Changlin, Oh Yuri, Feng Yujie, Wu Qiong, Effects of oral administration of titanium dioxide fine-sized particles on plasma glucose in mice. Food Chem Toxicol, 2015, 86:124-131.
4) Gu Ning, Guo Qian, Mao Ke, Hu Hailong, Jin Sanlin, Zhou Ying, He Hongjuan, Oh Yuri, Liu Chuanpeng, Wu Qiong, Plasmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes. Biochem Biophys Res Commun, 2015, 467: 521-526.
5) Hu Hailong, Guo Qian, Wang Changlin, Ma Xiao, He Hongjuan, Oh Yuri, Feng Yujie, Wu Qiong, Gu Ning, Titanium dioxide nanoparticles increase plasma glucose via reactive oxygen species-induced insulin resistance in mice. J. App. Toxicol. 2015.
6) Hu Hailong, Li Li, Wang Changlin, He Hongjuan, Mao Ke, Ma Xiao, Shi Ruoyu, Oh Yuri, Zhang Fengwei, Lu Ying, Wu Qiong, Gu Ning, 4-Phenylbutyric acid increases GLUT4 gene expression through suppression of HDAC5 but not endoplasmic reticulum stress. Cell Physiol Biochem. 2014;33(6):1899-910.
7) Wang CL, Diao YX, Xiang Q, Ren YK, Gu Ning, Diabetes attenuates the inhibitory effects of endomorphin-2, but not endomorphin-1 on gastrointestinal transit in mice. Eur J Pharmacol. 2014 Sep 5;738:1-7.
8) Wang CL, Xiang Q, Diao YX, Ren YK, Gu Ning, Differential antinociceptive effects of intrathecal administration of C-terminal esterified endomorphin-2 analogues in mice. Eur J Pain. 2014 Sep;18(8):1157-64.
9) Wang CL, Ren YK, Xiang Q, Wang Y, Gu Ning, Lu C, Wang R, Characterization of opioid activities of endomorphin analogs with C-terminal amide to hydrazide conversion. Neuropeptides. 2013 Oct;47(5):297-304.
10) Gu Tiantian, He Hongjuan, Xing Yanjiang, Liu Qi, Gu Ning, Sugimoto Kenkichi, Jiang Huijie and Wu Qiong. Expression of non-coding RNA AB063319 derived from Rian gene during mouse development. J Mol Histol. 2011 Feb 9 [Epub ahead of print]
11) Ikegami Dasuke, Iwai T, Ryo Senyi, Gu Ning, Sugiyama Tasuke, Oh Isamu, Yoshikawa Hiroyuki, Tsumaki Nobuyuki. Identification of small molecular compounds and fabrication of its aqueous solution by laser-ablation, expanding primordial cartilage. Osteoarthritis Cartilage. 19(2), 233-41 2011.
12) Gu Ning, Nagatomo Fumiko, Fujino Hidemi, Takeda Isao, Tsuda Kinsuke, Ishihara Akihiko. Effects of hyperbaric oxygenation on oxidative capacity in the soleus and plantaris muscles of type 2 diabetic rats. Diabetes Technol. Ther. 12(2):125-133, Feb, 2010.
13) Gu Ning, Tsuda Mariko, Matsunaga Tetsuro, Adachi Tetsuya, Yasuda Koichiro, Ishihara Akihiko, Tsuda Kinsuke. Glucose regulation of DPP-IV gene expression is mediated by HNF-1alpha in epithelial intestinal cells. Clin Exp Pharm Phys. 35(12), 1433-1439, May, 2008.
14) Gu Ning, Adachi Tetsuya, Matsunaga Tetsuro, Tsujimoto Gozoh, Ishihara Akihiko, Yasuda Koichiro, Tsuda Kinsuke. HNF-1alpha participates in glucose regulation of sucrase-isomaltase (SI) gene expressions in small intestinal epithelial cells. Biochem Biophys Res Commun. 353(3), 617-622, Feb, 2007.
15) Gu Ning, Adachi Tetsuya, Matsunaga Tetsuro, Takeda Jun, Tsujimoto Gozoh, Ishihara Akihiko, Yasuda Koichiro, Tsuda Kinsuke. Mutant HNF-1alpha and mutant HNF-1beta identified in MODY3 and MODY5 downregulate DPP-IV gene expression in Caco-2 cells. Biochem Biophys Res Commun. 346(3), 1016-1023, Aug, 2006.
16) Gu Ning, Adachi Tetsuya, Takeda Jun, Aoki Norihiko, Tsujimoto Gozoh, Ishihara Akihiko, Tsuda Kinsuke, Yasuda Koichiro. Sucrase-isomaltase gene expression is inhibited by mutant hepatocyte nuclear factor (HNF)-1alpha and mutant HNF-1beta in Caco-2 cells. J Nutrl Sci Vitaminol. 52(2), 105-112, Apr, 2006.
17) Gu Ning, Suzuki Naoko, Takeda Jun, Adachi Tetsuya, Tsujimoto Gozoh, Ishihara Akihiko,Tsuda Kinsuke, Yasuda Koichiro. Effect of mutations in HNF-1alpha and HNF-1beta on the transcriptional regulation of human sucrase-isomaltase (SI) in Caco-2 cells. Biochem Biophys Res Commun. 325(1), 308-313, Oct, 2004.
18) Nagatomo Fumiko, Gu Ning, Fujino Hidemi, Takeda Isao, Tsuda Kinsuke, Ishihara Akihiko. Characteristics of skeletal muscle in rats with diabetes, hypertension, obesity,and hyperlipidemia. J Atheroscler Thromb. 16(5), 576-585, Oct, 2009.
19) Nagatomo Fumiko, Gu Ning, Fujino Hidemi, Okiur Tomonori, Morimatsu Fumiki, Takeda Isao, Ishihara Akihiko. Effects of hyperbaric exposure with high oxygen concentration on reactive oxygen metabolites in type II collagen-induced arthritis rats. Free Radical Research (accepted Aug, 2009).
20) Matsunaga Tetsuro, Gu Ning, Yamazaki Hanae, Tsuda Mariko, Adachi Tetsuya, Yasuda ,Koichiro, Moritani, Toshio, Tsuda Kinsuke, Nonaka Masahiko, Nishiyama Tohru. Association of UCP2 and UCP3 polymorphisms with autonomic nervous system functionin young Japanese males. J Hypertens. 27(2), 305-313, 2009.
21) Okiura Tomonori, Nagatomo Fumiko, Gu Ning, Taguchi Yasuki, Morimatsu Fumiki and Ishihara Akihiko. Bone density of the femur and fFiber cross-sectional area and oxidative enzyme activity of the tibialis anterior muscle in type II collagen-induced arthritic mice. J Physiol Sci. 58(4), 221-227, 2008.
22) Koyanagi Midori, Nakabayashi Kazuhiko, Fujimoto Takahiro, Gu Ning, Baba Iwai, Sasazuki Takehiko and Shirasawa Senji. ZFAT expression in B and T lymphocytes andidentification of ZFAT-regulated genes. Genomics. 91(5), 451-457, 2008.
23) Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Matsumoto Akiko, Matsunaga Tetsuro, Tsujimoto Gozoh, Ishihara Akihiko. Effects of hyperbaric exposure with high oxygenconcentration on glucose and insulin levels and skeletal muscle fiber properties in diabetic Goto-Kakizaki rats. Muscle Nerve. 35(3), 337-343, 2007.
24) Matsunaga Tetsuro, Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Yamamura Tsubasa, Moritani Toshio, Tsujimoto Gozoh, Tsuda Kinsuke. Association of beta-adrenoceptor polymorphisms with cardiac autonomic modulation in Japanese males. Am Heart J.154(4), 759-766, 2007.
25) Adachi Tetsuya, Kikuchi Naoko, Yasuda Koichiro, Anahara Reko, Gu Ning, Matsunaga Tetsuro, Yamamura Tsubasa, Tsujimoto Gozou, Tsuda Kinsuke, Ishihara Akihiko. Fiber type distribution, succinate dehydrogenese and peroxisome proliferator- activatedreceptor gamma coactivator- 1alpha gene expression level of fibers in the soleus muscle of Zucker diabetic fatty rats. Exp Physiol. 92(2), 449-455, 2007.
26) Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Tsuda Kinsuke, Kikuchi Naoko, Matsunaga Tetsuro, Ishihara Akihiko. Hyperbaric exposure with high oxygen concentration inhibits growth-associated increase in the glucose level of diabetic Goto-Kakizaki rats. Diabetes Obes Metab. 8(6), 714-715, 2006.
27) Matsunaga Tetsuro, Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Yamamura Tsubasa, Moritani Toshio, Tsujimoto Gozoh, Tsuda Kinsuke. Alpha-adrenoceptor gene variants and autonomic nervous system function in a young healthy Japanese population. J Hum Genet. 52(1), 28-37, 2006.
28) Matsunaga Tetsuro, Nagasumi Kae, Gu Ning, Nishikino Mariko, Ueda Yukihiko, Moritani Toshio, Aoki Norihiko, Tsuda Kinsuke, Yasuda Koichiro. Association of C825T Polymorphism of G protein beta3 subunit with the autonomic nervous system in young healthy japanese individuals. Am J Hypertens. 18(4), 523-529, 2005.
29) Yasuda Koichiro, Matsunaga Tetsuro, Moritani Toshio, Nishikino Mariko, Gu Ning, Yoshinaga Mariko, Nagasumi Kae, Yamamura Tsubasa,, Tsuda Kinsuke. T393C polymorphism of GNAS1 associated with the autonomic nervous system in young, healthy Japanese subjects. Clin Exp Pharm Phys. 31(9), 597-601, 2004.